3117 Brucine Brucine is a plant toxin found in several species, most notably the Strychnine tree (Strychnos nux-vomica L.). Medically, brucine is primarily used in the regulation of high blood pressure and other comparatively benign cardiac ailments. (L1227) 357-57-3 442021 C23H26N2O4 394.46354 White powder. 178°C 3.2 mg/mL at 15°C [YALKOWSKY,SH & DANNENFELSER,RM (1992)] Oral (ingestion) (L1817) ; dermal (L1817) Brucine acts as an antagonist at the inhibitory or strychnine-sensitive glycine receptor, a ligand-gated chloride channel in the spinal cord and the brain. (L1230) LD50: 4 mg/kg (Oral, Rat) (T14) LD50: 91 mg/kg (Intraperitoneal, Rat) (T14) LD50: 60 mg/kg (Subcutaneous, Rat) (T14) No indication of carcinogenicity to humans (not listed by IARC). Brucine is a plant toxin found in several species, most notably the Strychnine tree (Strychnos nux-vomica L.). Medically, brucine is primarily used in the regulation of high blood pressure and other comparatively benign cardiac ailments. (L1227) Death may result from asphyxia or sheer exhaustion. (L1227) Brucine causes muscular convulsions of increasing intensity and frequency and eventually death through asphyxia or sheer exhaustion. (L1227) Treatment of brucine poisoning involves an oral application of an activated charcoal infusion to absorb any poison within the digestive tract that has not yet been absorbed into the blood. Anticonvulsants such as phenobarbital or diazepam are administered to control convulsions, along with muscle relaxants such as dantrolene to combat muscle rigidity. (L1228) 2009-07-23T18:26:04Z 2026-03-26T21:22:19Z http://en.wikipedia.org/wiki/Brucine C09084 Brucine 7136 true COC1=CC2=C(C=C1OC)C13CCN4CC5=CCOC6CC(=O)N2C1C6C5CC34 C23H26N2O4 InChI=1S/C23H26N2O4/c1-27-16-8-14-15(9-17(16)28-2)25-20(26)10-18-21-13-7-19-23(14,22(21)25)4-5-24(19)11-12(13)3-6-29-18/h3,8-9,13,18-19,21-22H,4-7,10-11H2,1-2H3 RRKTZKIUPZVBMF-UHFFFAOYSA-N 394.4635 394.18925733 Exogenous Solid 9270 CHEM002413 DTXSID2024662 NS00003564 4,5-dimethoxy-12-oxa-8,17-diazaheptacyclo[15.5.2.0¹,¹⁸.0²,⁷.0⁸,²².0¹¹,²¹.0¹⁵,²⁰]tetracosa-2(7),3,5,14-tetraen-9-one