<?xml version="1.0" encoding="UTF-8"?>
<compound>
  <id type="integer">3102</id>
  <title>T3D3060</title>
  <common-name>Phenindamine</common-name>
  <description>Phenindamine is an antihistamine. Phenindamine blocks the effects of the naturally occurring chemical histamine in your body. Antihistamines such as phenindamine appear to compete with histamine for histamine H1- receptor sites on effector cells. The antihistamines antagonize those pharmacological effects of histamine which are mediated through activation of H1- receptor sites and thereby reduce the intensity of allergic reactions and tissue injury response involving histamine release.  It is used to treat sneezing, runny nose, itching, watery eyes, hives, rashes, itching, and other symptoms of allergies and the common cold.Symptoms of a phenindamine overdose include extreme sleepiness, confusion, weakness, ringing in the ears, blurred vision, large pupils, dry mouth, flushing, fever, shaking, insomnia, hallucinations, and possibly seizures.</description>
  <cas>82-88-2</cas>
  <pubchem-id>11291</pubchem-id>
  <chemical-formula>C19H19N</chemical-formula>
  <weight>261.151750</weight>
  <appearance>White powder.</appearance>
  <melting-point>91°C</melting-point>
  <boiling-point nil="true"/>
  <density nil="true"/>
  <solubility>2.77e-02 g/L</solubility>
  <specific-gravity nil="true"/>
  <flash-point nil="true"/>
  <vapour-pressure nil="true"/>
  <route-of-exposure nil="true"/>
  <target nil="true"/>
  <mechanism-of-toxicity>Antihistamines such as phenindamine appear to compete with histamine for histamine H1- receptor sites on effector cells. The antihistamines antagonize those pharmacological effects of histamine which are mediated through activation of H1- receptor sites and thereby reduce the intensity of allergic reactions and tissue injury response involving histamine release.</mechanism-of-toxicity>
  <metabolism></metabolism>
  <toxicity nil="true"/>
  <lethaldose nil="true"/>
  <carcinogenicity>No indication of carcinogenicity to humans (not listed by IARC).</carcinogenicity>
  <use-source>Used to treat sneezing, runny nose, itching, watery eyes, hives, rashes, itching, and other symptoms of allergies and the common cold.</use-source>
  <min-risk-level nil="true"/>
  <health-effects nil="true"/>
  <symptoms>Symptoms of a phenindamine overdose include extreme sleepiness, confusion, weakness, ringing in the ears, blurred vision, large pupils, dry mouth, flushing, fever, shaking, insomnia, hallucinations, and possibly seizures.</symptoms>
  <treatment nil="true"/>
  <created-at type="dateTime">2009-07-21T20:28:56Z</created-at>
  <updated-at type="dateTime">2026-04-04T14:18:22Z</updated-at>
  <interacting-proteins nil="true"/>
  <wikipedia nil="true"/>
  <uniprot-id></uniprot-id>
  <kegg-compound-id>C07790</kegg-compound-id>
  <omim-id></omim-id>
  <chebi-id>130096</chebi-id>
  <biocyc-id></biocyc-id>
  <ctd-id nil="true"/>
  <stitch-id>Phenindamine</stitch-id>
  <drugbank-id>DB01619</drugbank-id>
  <pdb-id></pdb-id>
  <actor-id nil="true"/>
  <organism nil="true"/>
  <export type="boolean">true</export>
  <metabolizing-proteins nil="true"/>
  <transporting-proteins nil="true"/>
  <moldb-smiles>CN1CCC2=C(C1)C(C1=CC=CC=C21)C1=CC=CC=C1</moldb-smiles>
  <moldb-formula>C19H19N</moldb-formula>
  <moldb-inchi>InChI=1S/C19H19N/c1-20-12-11-16-15-9-5-6-10-17(15)19(18(16)13-20)14-7-3-2-4-8-14/h2-10,19H,11-13H2,1H3</moldb-inchi>
  <moldb-inchikey>ISFHAYSTHMVOJR-UHFFFAOYSA-N</moldb-inchikey>
  <moldb-average-mass type="decimal">261.3609</moldb-average-mass>
  <moldb-mono-mass type="decimal">261.151749613</moldb-mono-mass>
  <origin>Exogenous</origin>
  <state>Solid</state>
  <logp nil="true"/>
  <hmdb-id>HMDB15556</hmdb-id>
  <chembl-id>CHEMBL278398</chembl-id>
  <chemspider-id>10817</chemspider-id>
  <structure-image-file-name nil="true"/>
  <structure-image-content-type nil="true"/>
  <structure-image-file-size type="integer" nil="true"/>
  <structure-image-updated-at type="dateTime" nil="true"/>
  <biodb-id nil="true"/>
  <synthesis-reference></synthesis-reference>
  <structure-image-caption nil="true"/>
  <chemdb-id>CHEM002404</chemdb-id>
  <dsstox-id>DTXSID0023452</dsstox-id>
  <toxcast-id nil="true"/>
  <stoff-ident-origin nil="true"/>
  <stoff-ident-id nil="true"/>
  <susdat-id>NS00038226</susdat-id>
  <iupac>2-methyl-9-phenyl-1H,2H,3H,4H,9H-indeno[2,1-c]pyridine</iupac>
</compound>
