3031 T3D2989 Chlorpheniramine Chlorpheniramine is a histamine H1 antagonist used in allergic reactions, hay fever, rhinitis, urticaria, and asthma. It has also been used in veterinary applications. One of the most widely used of the classical antihistaminics, it generally causes less drowsiness and sedation than Promethazine. -- Pubchem; Chlorphenamine or chlorpheniramine, commonly marketed as its salt chlorphenamine maleate (Chlor- Trimeton, Piriton, Chlor- Tripolon), is a first generation antihistamine used in the prevention of the symptoms of allergic conditions such as rhinitis and urticaria.- wikipedia. 132-22-9 2725 C16H19ClN2 274.123680 White powder. 130 - 135°C 142°C 5500 mg/L (at 37°C) Well absorbed in the gastrointestinal tract. Chlorpheniramine binds to the histamine H1 receptor. This blocks the action of endogenous histamine, which subsequently leads to temporary relief of the negative symptoms brought on by histamine. Primarily hepatic via Cytochrome P450 (CYP450) enzymes. Half Life: 21-27 hours Oral LD50 (rat): 306 mg/kg Oral LD50 (mice): 130 mg/kg Oral LD50 (guinea pig): 198 mg/kg LD50: 306 mg/kg (Human) (A308) No indication of carcinogenicity to humans (not listed by IARC). Used used in the prevention of the symptoms of allergic conditions such as rhinitis, urticaria, allergy, common cold, asthma and hay fever. Chlorpheniramine posesses serotonergic and norepinephrinergic effects. It has been shown to work as a serotonin-norepinephrine reuptake inhibitor or SNRI. [Wikipedia] 2009-07-21T20:28:24Z 2026-05-14T16:57:56Z Chlorpheniramine C06905 146840 52010 Chlorpheniramine DB01114 true CN(C)CCC(C1=CC=C(Cl)C=C1)C1=CC=CC=N1 C16H19ClN2 InChI=1S/C16H19ClN2/c1-19(2)12-10-15(16-5-3-4-11-18-16)13-6-8-14(17)9-7-13/h3-9,11,15H,10,12H2,1-2H3 SOYKEARSMXGVTM-UHFFFAOYSA-N 274.788 274.123676325 Exogenous Solid 3.38 HMDB01944 CHEMBL505 2624 <p>Anil M. Salpekar, John Johnson, &#8220;Acetaminophen compositions containing low doses of chlorpheniramine maleate, method for preparing same and tablets formed therefrom.&#8221; U.S. Patent US4631284, issued April, 1975.</p> CHEM002350 DTXSID50180225 NS00098761 [3-(4-chlorophenyl)-3-(pyridin-2-yl)propyl]dimethylamine 16.130000000000003 80.8503 30.821200958347674 5 2 0 9.474711663883962 1 2 3.74 -3.72 5.19e-02 g/l