2979 Felbamate Felbamate is an anticonvulsant drug used in the treatment of epilepsy. It is used to treat partial seizures (with and without generalization) in adults and partial and generalized seizures associated with Lennox-Gastaut syndrome in children. It has a weak inhibitory effect on GABA receptor binding sites. 25451-15-4 3331 C11H14N2O4 238.095360 White powder. 151.5°C Slightly soluble in water Oral. >90% The mechanism by which felbamate exerts its anticonvulsant activity is unknown, but in animal test systems designed to detect anticonvulsant activity, felbamate has properties in common with other marketed anticonvulsants. <i>In vitro</i> receptor binding studies suggest that felbamate may be an antagonist at the strychnine-insensitive glycine-recognition site of the N-methyl-D-aspartate (NMDA) receptor-ionophore complex. Antagonism of the NMDA receptor glycine binding site may block the effects of the excitatory amino acids and suppress seizure activity. Animal studies indicate that felbamate may increase the seizure threshold and may decrease seizure spread. It is also indicated that felbamate has weak inhibitory effects on GABA-receptor binding, benzodiazepine receptor binding. Hepatic Half Life: 20-23 hours LD50: 5000 mg/kg (Oral, Rat) (A308) No indication of carcinogenicity to humans (not listed by IARC). For use only in those patients who respond inadequately to alternative treatments and whose epilepsy is so severe that a substantial risk of aplastic anemia and/or liver failure is deemed acceptable in light of the benefits conferred by its use. May cause a potentially dangerous rash that may develop into Stevens Johnson syndrome, an extremely rare but potentially fatal skin disease. General supportive measures should be employed if overdosage occurs. It is not known if felbamate is dialyzable. (L1712) 2009-07-21T20:28:00Z 2026-03-31T19:04:29Z Felbamate C07501 4995 Felbamate DB00949 true NC(=O)OCC(COC(N)=O)C1=CC=CC=C1 C11H14N2O4 InChI=1S/C11H14N2O4/c12-10(14)16-6-9(7-17-11(13)15)8-4-2-1-3-5-8/h1-5,9H,6-7H2,(H2,12,14)(H2,13,15) WKGXYQFOCVYPAC-UHFFFAOYSA-N 238.2399 238.095356946 Exogenous Solid 0.3 HMDB15084 CHEMBL1094 3214 CHEM002308 DTXSID9023041 NS00010360 3-(carbamoyloxy)-2-phenylpropyl carbamate