2928 T3D2886 Olopatadine Used to treat allergic conjunctivitis (itching eyes), olopatadine inhibits the release of histamine from mast cells. It is a relatively selective histamine H1 antagonist that inhibits the in vivo and in vitro type 1 immediate hypersensitivity reaction including inhibition of histamine induced effects on human conjunctival epithelial cells. 113806-05-6 5281071 C21H23NO3 337.167790 White powder. 248°C Soluble Ophthalmic use of olopatadine usually does not produce measurable plasma concentrations. Olopatadine is a selective histamine H1 antagonist that binds to the histamine H1 receptor. This blocks the action of endogenous histamine, which subsequently leads to temporary relief of the negative symptoms brought on by histamine. Olopatadine is devoid of effects on alpha-adrenergic, dopamine and muscarinic type 1 and 2 receptors. The mono-desmethyl and the N-oxide metabolites have been detected at low concentrations in the urine. Route of Elimination: Elimination was predominantly through renal excretion. Half Life: 3 hours No indication of carcinogenicity to humans (not listed by IARC). For the treatment of ocular itching associated with allergic conjunctivitis. Used as an antihistamine. [Wikipedia] Its side effects may include headaches (7% of occurrence) burning and stinging (5%), dry eye, foreign body sensation, hyperemia, keratitis, lid edema, pruritus, asthenia, cold syndrome, pharyngitis, rhinitis, sinusitis, and taste perversion. [Wikipedia] 2009-07-21T20:27:37Z 2026-05-14T16:48:21Z Olopatadine C07789 763382 Olopatadine DB00768 true CN(C)CC\C=C1\C2=CC=CC=C2COC2=C1C=C(CC(O)=O)C=C2 C21H23NO3 InChI=1S/C21H23NO3/c1-22(2)11-5-8-18-17-7-4-3-6-16(17)14-25-20-10-9-15(12-19(18)20)13-21(23)24/h3-4,6-10,12H,5,11,13-14H2,1-2H3,(H,23,24)/b18-8- JBIMVDZLSHOPLA-LSCVHKIXSA-N 337.4122 337.167793607 Exogenous Solid 3.4 HMDB14906 CHEMBL1189432 4444528 <p>Thomas Bader, Hans-Ulrich Bichsel, Bruno Gilomen, Imelda Meyer-Wilmes, Mark Sundermeier, &#8220;Polymorphic forms of olopatadine hydrochloride and methods for producing olopatadine and salts thereof.&#8221; U.S. Patent US20070232814, issued October 04, 2007.</p> CHEM002269 DTXSID3023390 NS00000615 2-[(2Z)-2-[3-(dimethylamino)propylidene]-9-oxatricyclo[9.4.0.0^{3,8}]pentadeca-1(15),3(8),4,6,11,13-hexaen-5-yl]acetic acid 49.77 109.55240000000002 37.43942240395542 5 4 1 3.7840305278312574 9.760738756803887 0 3 3.99 -4.03 3.13e-02 g/l