2925 Ethotoin Ethotoin is a hydantoin derivative and anticonvulsant. Ethotoin exerts an antiepileptic effect without causing general central nervous system depression. The mechanism of action is probably very similar to that of phenytoin. The latter drug appears to stabilize rather than to raise the normal seizure threshold, and to prevent the spread of seizure activity rather than to abolish the primary focus of seizure discharges. Ethotoin is no longer commonly used. 86-35-1 3292 C11H12N2O2 204.089880 White powder. 94°C 5280 mg/L Fairly rapidly absorbed, however, the extent of oral absorption is not known. The mechanism of action is probably very similar to that of phenytoin. The latter drug appears to stabilize rather than to raise the normal seizure threshold, and to prevent the spread of seizure activity rather than to abolish the primary focus of seizure discharges. Ethotoin inhibits nerve impulses in the motor cortex by lowering sodium ion influx, limiting tetanic stimulation. Hepatic. The drug exhibits saturable metabolism with respect to the formation of N-deethyl and p-hydroxyl-ethotoin, the major metabolites. Half Life: 3 to 9 hours No indication of carcinogenicity to humans (not listed by IARC). For the control of tonic-clonic (grand mal) and complex partial (psychomotor) seizures. May cause a potentially dangerous rash that may develop into Stevens Johnson syndrome, an extremely rare but potentially fatal skin disease. Symptoms of overdose include drowsiness, loss of or impaired muscle coordination, nausea, visual disturbance, and, at very high doses, coma. Treatment should be begun by inducing emesis; gastric lavage may be considered as an alternative. General supportive measures will be necessary. A careful evaluation of blood-forming organs should be made following recovery. (L1712) 2009-07-21T20:27:35Z 2026-04-04T15:32:38Z Ethotoin C07839 4888 Ethotoin DB00754 true CCN1C(=O)NC(C1=O)C1=CC=CC=C1 C11H12N2O2 InChI=1S/C11H12N2O2/c1-2-13-10(14)9(12-11(13)15)8-6-4-3-5-7-8/h3-7,9H,2H2,1H3,(H,12,15) SZQIFWWUIBRPBZ-UHFFFAOYSA-N 204.2252 204.089877638 Exogenous Solid 1.05 HMDB14892 CHEMBL1095 3176 <p>Close, W.J.; U.S. Patent 2,793,157; May 21, 1957; assigned to Abbott Laboratories.</p> CHEM002267 DTXSID6023020 NS00039122 3-ethyl-5-phenylimidazolidine-2,4-dione