2825 Pramipexole Pramipexole is a medication indicated for treating Parkinson's disease and restless legs syndrome (RLS). It is also sometimes used off-label as a treatment for cluster headache or to counteract the problems with low libido experienced by some users of SSRI antidepressant drugs. Pramipexole has shown robust effects on pilot studies in bipolar disorder. Pramipexole is classified as a non-ergoline dopamine agonist. 104632-26-0 119570 C10H17N3S 211.114320 White powder. 1.40e-01 g/L Oral, rapid. Absolute bioavailability is greater than 90%, indicating that pramipexole is well absorbed and undergoes little presystemic metabolism. Food does not affect the extent of absorption. The precise mechanism of action of Pramipexole as a treatment for Parkinson's disease is unknown, although it is believed to be related to its ability to stimulate dopamine receptors in the striatum. No metabolites have been identified in plasma or urine. Route of Elimination: Urinary excretion is the major route of pramipexole elimination, with 90% of a pramipexole dose recovered in urine, almost all as unchanged drug. Nonrenal routes may contribute to a small extent to pramipexole elimination, although no metabolites have been identified in plasma or urine. Half Life: 8 hours No indication of carcinogenicity to humans (not listed by IARC). For the treatment of signs and symptoms of idiopathic Parkinson's disease There is no known antidote for overdosage of a dopamine agonist. If signs of central nervous system stimulation are present, a phenothiazine or other butyrophenone neuroleptic agent may be indicated; the efficacy of such drugs in reversing the effects of overdosage has not been assessed. Management of overdose may require general supportive measures along with gastric lavage, intravenous fluids, and electrocardiogram monitoring. (L1712) 2009-07-21T20:26:50Z 2026-05-14T16:38:03Z Pramipexole 8356 Pramipexole DB00413 true CCCN[C@H]1CCC2=C(C1)SC(N)=N2 C10H17N3S InChI=1S/C10H17N3S/c1-2-5-12-7-3-4-8-9(6-7)14-10(11)13-8/h7,12H,2-6H2,1H3,(H2,11,13)/t7-/m0/s1 FASDKYOPVNHBLU-ZETCQYMHSA-N 211.327 211.114318249 Exogenous Solid 0.4 HMDB14557 CHEMBL301265 106770 <p><a href="http://www.drugsyn.org/Pramipexole.htm">DrugSyn.org</a></p> CHEM002189 DTXSID6023496 NS00098767 (6S)-N6-propyl-4,5,6,7-tetrahydro-1,3-benzothiazole-2,6-diamine 50.94 59.7672 24.468695615682893 3 3 2 17.661047871514864 10.310439610499934 1 2 2.18 -3.18 1.40e-01 g/l