2802 Trimethadione Trimethadione is only found in individuals that have used or taken this drug. It is an anticonvulsant effective in absence seizures, but generally reserved for refractory cases because of its toxicity. (From AMA Drug Evaluations Annual, 1994, p378) Trimethadione reduces T-type calcium currents in thalamic neurons, including thalamic relay neurons. It does so via the inhibition of voltage dependent T-type calcium channels. This raises the threshold for repetitive activity in the thalamus, and inhibits corticothalamic transmission. Thus, the abnormal thalamocortical rhythmicity, which is thought to underlie the 3-Hz spike-and-wave discharge seen on electroencephalogram(EEG) with absence seizures, is dampened. 127-48-0 5576 C6H9NO3 143.058240 White powder. 46°C 5E+004 mg/L Dione anticonvulsants reduce T-type calcium currents in thalamic neurons, including thalamic relay neurons. It does so via the inhibition of voltage dependent T-type calcium channels. This raises the threshold for repetitive activity in the thalamus, and inhibits corticothalamic transmission. Thus, the abnormal thalamocortical rhythmicity, which is thought to underlie the 3-Hz spike-and-wave discharge seen on electroencephalogram(EEG) with absence seizures, is dampened. No indication of carcinogenicity to humans (not listed by IARC). Used in the control of absence (petit mal) seizures that are refractory to treatment with other medications. May cause a potentially dangerous rash that may develop into Stevens Johnson syndrome, an extremely rare but potentially fatal skin disease. Symptoms of overdose include clumsiness or unsteadiness, coma, dizziness (severe), drowsiness (severe), nausea (severe), and problems with vision. 2009-07-21T20:26:40Z 2026-05-14T16:36:07Z Trimethadione 131804 Trimethadione DB00347 true CN1C(=O)OC(C)(C)C1=O C6H9NO3 InChI=1S/C6H9NO3/c1-6(2)4(8)7(3)5(9)10-6/h1-3H3 IRYJRGCIQBGHIV-UHFFFAOYSA-N 143.1406 143.058243159 Exogenous Solid 0 HMDB14491 CHEMBL695 5374 CHEM002179 DTXSID9021396 NS00024046 trimethyl-1,3-oxazolidine-2,4-dione 46.61000000000001 33.200199999999995 13.58846152502696 0 2 0 0 1 0.07 0.17 2.12e+02 g/l