2603 T3D2562 Gamma-Butyrolactone One of the furans with a carbonyl thereby forming a cyclic lactone. It is an endogenous compound made from gamma-aminobutyrate and is the precursor of gamma-hydroxybutyrate. It is also used as a pharmacological agent and solvent. 96-48-0 7302 C4H6O2 86.036780 Colorless oily liquid (L1140). -45°C 1000.0 mg/mL Inhalation (A626) ; oral (A626) ; injection (A626) ; dermal (A626). Gamma-butyrolactone is rapidly converted to gamma-hydroxybutyrate. This may account for the subsequent central nervous system depressant. Gamma-butyrolactone is an anesthetic that causes a selective increase in brain dopamine by antagonizing transmitter release from nerve terminal. It is also an endogenous brain metabolite that may be derived from glutamate through gamma-aminobutyrate. GBL binds to the picrotoxin receptor (A566, A318). Gamma-Butyrolactone undergoes rapid and quantitative conversion by lactonases, yielding gamma-hydroxybutyric acid (A627). LD50: 17.2 mL/kg (Oral, Rat) (581) 3, not classifiable as to its carcinogenicity to humans. (L135) Common solvent and reagent in chemistry and is used as an aroma compound, as a stain remover, as a superglue remover, as a paint stripper, and as a solvent in some wet aluminium electrolytic capacitors (L1140). CNS depression; amnesia and hypotonia. Rarely, hypertension, orthostatic hypotension, apnea, dyskinesias, dystonias, and hypomania occur. Headache, confusion, ataxia, urinary incontinence or urgency, difficulty breathing, bradycardia, uncontrollable shaking, hallucinations, seizure-like activity (uncontrollable or unusual movements), and acidosis. Hypothermia has been reported in adults and children following exposure (T36). In case of oral exposure, administer a benzodiazepine IV. There is no antidote. Treatment is symptomatic and supportive. (T36) 2009-07-05T03:12:29Z 2026-03-26T21:07:39Z http://en.wikipedia.org/wiki/4-Hydroxybutyric acid lactone C01770 42639 CPD-10135 D015107 Butyrolactone, gamma- DB04699 GBL 227 true O=C1CCCO1 C4H6O2 InChI=1S/C4H6O2/c5-4-2-1-3-6-4/h1-3H2 YEJRWHAVMIAJKC-UHFFFAOYSA-N 86.0892 86.036779436 Endogenous Liquid -0.64 HMDB00549 CHEMBL95681 7029 <p>Fabio Giannessi, Maria Ornella Tinti, Francesco De Angelis, &#8220;Process for producing&#174;-3-hydroxy-4-butyrolactone useful for preparing&#174;-carnitine.&#8221; U.S. Patent US6127552, issued February, 1998.</p> CHEM002088 DTXSID6020224 oxolan-2-one