2513 Phallacin Phallacin is one of a group of toxins from the death cap (Amanita phalloides) known as phallotoxins. The phallotoxins consist of at least seven compounds, all of which have seven similar peptide rings, isolated from the death cap (Amanita phalloides). (L996) 53568-40-4 171277 C37H50N8O12S 830.9043 White powder. Oral, dermal, inhalation, and parenteral (contaminated drugs). (A3101) Phallotoxins bind actin, preventing its depolymerization and poisoning the cell. They bind specifically at the interface between F-actin subunits, locking adjacent subunits together. This leads to a decrease in the rate constant for the dissociation of actin subunits from filament ends, which essentially stabilizes actin filaments through the prevention of filament depolymerization. Moreover, they inhibit the ATP hydrolysis activity of F-actin. (L1183, A2465) LD50: 1.5 mg/kg (Mouse) (T258) No indication of carcinogenicity to humans (not listed by IARC). Phallacidin is one of a group of toxins from the death cap (Amanita phalloides) known as phallotoxins. (L996) Liver lesions, tachycardia, hypoglycemia, hypotension and electrolyte imbalance with acid- base disturbance (L1160). Hypovolemic shock; Gastrointestinal symptoms occur after a latent period and include abdominal pain, vomiting, and watery diarrhea. Neurologic symptoms are related to hepatic failure and may include encephalopathy, somnolence, confusion, coma and seizures (L1160). Consider gastric lavage and activated charcoal. (A678) 2009-07-03T21:46:57Z 2026-04-06T12:09:49Z Phallacin true CC(C)C1N=C(O)C(CC(C)(C)O)N=C(O)C2CC3=C(NC4=CC=CC=C34)SCC(N=C(O)C(N=C1O)C(O)C(O)=O)C(=O)N1CC(O)CC1C(O)=NC(C)C(O)=N2 C37H50N8O12S InChI=1S/C37H50N8O12S/c1-15(2)25-32(52)44-26(27(47)36(55)56)33(53)41-23-14-58-34-19(18-8-6-7-9-20(18)42-34)11-21(29(49)40-22(30(50)43-25)12-37(4,5)57)39-28(48)16(3)38-31(51)24-10-17(46)13-45(24)35(23)54/h6-9,15-17,21-27,42,46-47,57H,10-14H2,1-5H3,(H,38,51)(H,39,48)(H,40,49)(H,41,53)(H,43,50)(H,44,52)(H,55,56) LAVFLHFIXHMDLZ-UHFFFAOYSA-N 830.904 830.326889794 Exogenous Solid 149740 CHEM002057 NS00123066 329.62999999999994 206.25760000000008 82.56185117963525 5 18 11 2.3269348559850003 5.446897046969477 -1 5 0.68 -3.75 1.48e-01 g/l