2414 Gallium phosphide Gallium phosphide is a phosphide of gallium. It is a semiconductor and optical material that is used for manufacture of low and standard brightness red, orange, and green light-emitting diodes. Metal phosphides are hydrolysed to phosphine upon contact with water or stomach acid. Phosphine is a colorless, flammable, explosive, and toxic gas. (L980, L985) 12063-98-8 82901 GaH3P 99.899340 Orange solid. 1477°C, 1750°K, 2691°F Oral (L982) ; inhalation (L982) Phosphine inhibits cytochrome c oxidase, preventing mitochondrial oxidative phosphorylation. This non-competitive inhibition prevents cellular respiration and leads to multi-organ dysfunction. Phosphine can also react with hydrogen peroxide to form the highly reactive hydroxyl radical, which can cause lipid peroxidation. (A291, A292) Phosphine and metal phosphides may be absorbed following ingestion or inhalation, then distribute to the nervous system, liver, and kidney. In the body, metal phosphides are hydrolysed to phosphine, and phosphine is oxidized to hypophosphite and phosphite. Metabolites are excreted in the urine, while unchanged phosphine is exhaled. (L982) No indication of carcinogenicity to humans (not listed by IARC). Gallium phosphide is a semiconductor and optical material that is used for manufacture of low and standard brightness red, orange, and green light-emitting diodes. (L985) Inhalation of phosphine may cause severe pulmonary irritation leading to acute pulmonary oedema, cardiovascular dysfunction, CNS excitation, coma and death. Gastrointestinal disorders, renal damage and leukopenia may also occur. Chronic exposure to phosphine can result in anemia, bronchitis, gastrointestinal effects, and visual, speech and motor problems. (L980, L982) Early symptoms of acute phosphine intoxication include pain in the diaphragm, nausea, vomiting, excitement, and a phosphorus smell on the breath. Higher levels can cause weakness, bronchitis, pulmonary edema, shortness of breath, convulsions, and death. Some effects, such as pulmonary edema, convulsions, and liver injury, may appear or continue to be present days after an exposure. Ingestion of metal phosphides results in release of phosphine in your stomach which can cause nausea, vomiting, abdominal pain, and diarrhea. (L980) As there is no antidote for phosphine poisoning, treatment is mainly symptomatic. Artificial respiration, gastric lavage, and/or administration of activated charcoal may be necessary. (L982) 2009-07-02T16:02:14Z 2016-11-09T01:08:39Z C485338 Gallium phosphide true P.[Ga] GaH3P InChI=1S/Ga.H3P/h;1H3 ZETOOLHODJOIKC-UHFFFAOYSA-N 103.721 102.922811 Exogenous Solid 74803 CHEM001999 gallane phosphane