977 Fosamine Fosamine is an organophosphate herbicide. Used as a foliar spray for control and/or growth suppression of many woody plant species such as maple, birch, alder, blackberry, vine maple, ash, and oak. Susceptible treated plants normally fail to refoliate during the growing season following treatment and subsequently die. Fosamine functions as a plant growth regulator. It is sometimes referred to as a “dormancy enforcer,” but its specific mechanism of action has not been identified. There is some evidence that it inhibits mitosis in susceptible plants. 59682-52-9 33257 C3H8NO4P 153.019090 White powder. Inhalation (L793) ; oral (L793); dermal (L793) Fosamine is an eye irritant. It likely binds to or modifies the TRPA1 protein which leads to a lachrymatory (tearing) response. Metabolism of organophosphates occurs principally by oxidation, and hydrolysis by esterases and by reaction with glutathione. Demethylation and glucuronidation may also occur. Oxidation of organophosphorus pesticides may result in moderately toxic products. In general, phosphorothioates are not directly toxic but require oxidative metabolism to the proximal toxin. The glutathione transferase reactions produce products that are, in most cases, of low toxicity. Fosamine rapidly passes through the body; elimination is primarily in the feces and less in the urine. It does not bioaccumulate (build up) in mammals. The oral LD50 is 24,400 mg/kg for rats No indication of carcinogenicity to humans (not listed by IARC). Used as a herbicide to control growth of woody plants. Occupational exposure to fosamine occurs through dermal contact and inhalation of dust and sprays, especially to workers applying the compound as a herbicide. Fosamine has low to very low toxicity if individuals accidentally inhale or eat residues and has moderate toxicity if touched. It is not irritating to the eyes, but it can cause mild to moderate skin irritation. Fosamine can cause moderate eye injury or irritation. In one subchronic oral study, the laboratory animals given the highest dose exhibited some statistically significant effects, including effects to the kidneys, bladder and decreases in body weight. Fosamine has low to very low toxicity if individuals accidentally inhale or eat residues and has moderate toxicity if touched. It is not irritating to the eyes, but it can cause mild to moderate skin irritation. Fosamine is not a skin sensitizer. For acute exposures and first aid: EYES: irrigate opened eyes for several minutes under running water. INGESTION: do not induce vomiting. Rinse mouth with water (never give anything by mouth to an unconscious person). Seek immediate medical advice. SKIN: should be treated immediately by rinsing the affected parts in cold running water for at least 15 minutes, followed by thorough washing with soap and water. If necessary, the person should shower and change contaminated clothing and shoes, and then must seek medical attention. INHALATION: supply fresh air. If required provide artificial respiration. 2009-06-17T23:53:03Z 2016-11-09T01:08:22Z C18789 C019397 Fosamine true CCOP(O)(=O)C(N)=O C3H8NO4P InChI=1S/C3H8NO4P/c1-2-8-9(6,7)3(4)5/h2H2,1H3,(H2,4,5)(H,6,7) UCHDFLNGIZUADY-UHFFFAOYSA-N 153.0737 153.019094261 Exogenous Solid 30725 CHEM000833 carbamoyl(ethoxy)phosphinic acid