811 Alachlor Selective preemergent herbicide used on food crops. Alachlor belongs to the family of Anilides. These are organic compounds derived fromA oxoacidsA RkE(=O)l(OH)mA (lA a 0) by replacing anA OHA group by theA NHPh group or derivative formed by ring substitution. 15972-60-8 2078 C14H20ClNO2 269.118260 White or cream, combustible crystalline solid without odour (L922). 39.5 - 41.5°C 0.24 mg/mL at 25°C oral (L922) ; dermal (L922) Its mode of action is elongase inhibition, and inhibition of geranylgeranyl pyrophosphate (GGPP) cyclisation enzymes. It is also know to inhibit biosynthesis of fatty acids, lipids, protein, isoprenoids, flavonoids, and gibberellins. (L921, L923). Alachlor is metabolized and eliminated as conjugates of mercapturic acid, glucuronic acid, and sulfate in the urine and feces (T18). LD50: 930 - 1360 mg/kg (Oral, Rat) (L922) LD50: 13 300 mg/kg (Dermal, Rabbit) (L922) No indication of carcinogenicity to humans (not listed by IARC). It is used mainly to control annual grasses and broadleaf weeds in corn (maize), soybeans, and peanuts (L921). ARDS/acute lung injury, burns of the esophagus or gastrointestinal tract can result from acetochlor poisoning (T36). Alachlor is mildly irritating to the skin and eyes. Exposure to metalaxyl often results in such nonspecific symptoms as headache, dizziness, weakness, and nausea. Alachlor poisoning can produce an allergic hypersensitivity dermatitis or asthma with bronchospasm and wheezing with chronic exposure (T36). 2009-06-05T16:50:55Z 2026-03-25T19:42:46Z Glutathione transferases mediathe the conjugation of alachlor with with glutathione; alachlor inhibits elongase, and geranylgeranyl pyrophosphate (GGPP) cyclisation enzymes . It also binds to human albumine (A270, L920, A273). C10928 2533 C000188 Alachlor 2151 true Glutathione S-transferase P (P09211) Glutathione S-transferase Mu 1 (P09488) Glutathione S-transferase A1 (P08263) Glutathione S-transferase theta-2 (P30712) Glutathione S-transferase Mu 4 (Q03013) Glutathione S-transferase theta-1 (P30711) Glutathione S-transferase A4 (O15217) Glutathione S-transferase A2 (P09210) Glutathione S-transferase A3 (Q16772) Glutathione S-transferase Mu 3 (P21266) Glutathione S-transferase omega-1 (P78417) Glutathione S-transferase kappa 1 (Q9Y2Q3) Glutathione S-transferase Mu 2 (P28161) Glutathione S-transferase omega-2 (Q9H4Y5) Glutathione S-transferase A5 (Q7RTV2) Glutathione S-transferase Mu 5 (P46439) Glutathione S-transferase theta-4 (A8MPT4) Maleylacetoacetate isomerase (O43708) Microsomal glutathione S-transferase 1 (P10620) Microsomal glutathione S-transferase 2 (Q99735) Microsomal glutathione S-transferase 3 (O14880) (A270, L920, A273) Serum albumin (P02768) (A270, L920, A273) CCC1=CC=CC(CC)=C1N(COC)C(=O)CCl C14H20ClNO2 InChI=1S/C14H20ClNO2/c1-4-11-7-6-8-12(5-2)14(11)16(10-18-3)13(17)9-15/h6-8H,4-5,9-10H2,1-3H3 XCSGPAVHZFQHGE-UHFFFAOYSA-N 269.767 269.118256596 Exogenous Solid 3.52 HMDB31766 CHEMBL1414154 1994 CHEM000722 DTXSID1022265 NS00000252 2-chloro-N-(2,6-diethylphenyl)-N-(methoxymethyl)acetamide