250 Dibromochloromethane Dibromochloromethane (and bromoform also known as tribromomethane) are colorless to yellow, heavy, nonburnable liquids with a sweetish odor. These chemicals are possible contaminants of drinking water that has been chlorinated. Bromoform and dibromochloromethane may form when chlorine reacts with other naturally occurring substances in water, such as decomposing plant material. Plants in the ocean also produce small amounts of these chemicals. Carcinogenic effects have been observed in animals exposed to bromoform and dibromochloromethane. Dibromochloromethane induced liver tumors in male and female mice. The primary targets of bromoform and dibromochloromethane toxicit are liver, kidney, and central nervous system. 124-48-1 31296 CHBr2Cl 205.813350 Colorless to pale yellow liquid. (L1173) -20°C 120 °C 2.451 g/cm3 (at 20 °C) 2.7 mg/mL at 20 °C [HEIKES,DL (1987)] Oral (L1173) ; inhalation (L1173) ; dermal (L1173) Dibromochloromethane is oxidized into trihalomethanol by the cytochrome P-450 mixed function oxidase system of liver. Trihalomethanol then decomposes by loss of hydrogen and halide ions to yield the dihalocarbonyl (an analogue of phosgene), which is a highly reactive molecule, and may undergo a number of reactions, including direct reaction with cellular nucleophiles to yield covalent adducts, reaction with two moles of glutathione (GSH) to yield CO and oxidized glutathione (GSSG), and hydrolysis to yield CO2. The fraction of the dose converted to carbon monoxide has not been quantified, but dramatically increased levels of carboxyhemoglobin have been reported following oral exposure of rats to bromoform. (L1173) In humans and laboratory animals, dibromochloromethane (and bromoform) are generally absorbed quickly. Dibromochloromethane (and bromoform) are thought to be metabolized by at least two route-independent pathways: oxidation by cytochrome P-450 mixed function oxidase system and conjugation via glutathione S-transferase. After ingestion, excretion occurs primarily by exhalation of the compound or of CO2. (L1173) 3, not classifiable as to its carcinogenicity to humans. (L135) Dibromochloromethane exposition occurs by drinking water that has been treated with chlorine, at a swimming pool, by breathing bromoform or dibromochloromethane that has evaporated into the air, or by uptake from the water through the skin. Neither dibromochloromethane nor bromoform are likely to be found in food. (L1173) Exposure to dibromochloromethane leads to central nervous system depression, which is probably the chief cause of death in acute exposures. Some studies in animals indicate that exposure to high doses of dibromochloromethane may also lead to liver and the kidney injury within a short period of time. (L1173) EYES: irrigate opened eyes for several minutes under running water. INGESTION: do not induce vomiting. Rinse mouth with water (never give anything by mouth to an unconscious person). Seek immediate medical advice. SKIN: should be treated immediately by rinsing the affected parts in cold running water for at least 15 minutes, followed by thorough washing with soap and water. If necessary, the person should shower and change contaminated clothing and shoes, and then must seek medical attention. INHALATION: supply fresh air. If required provide artificial respiration. 2009-03-06T18:58:22Z 2026-03-27T00:49:41Z http://en.wikipedia.org/wiki/Dibromochloromethane C14692 CPD-10560 C032707 Dibromochloromethane 302 true ClC(Br)Br CHBr2Cl InChI=1S/CHBr2Cl/c2-1(3)4/h1H GATVIKZLVQHOMN-UHFFFAOYSA-N 208.28 205.813353033 Exogenous Liquid HMDB59903 CHEMBL157093 29036 CHEM000218 DTXSID1020300 dibromo(chloro)methane