<?xml version="1.0" encoding="UTF-8"?>
<compound>
  <id type="integer">181</id>
  <title>T3D0180</title>
  <common-name>Palladium</common-name>
  <description>Palladium is a rare and lustrous silvery-white metal. Palladium has the lowest melting point and is the least dense of platinum group metals. The primary use for palladium is in catalytic converters for the automotive industry.</description>
  <cas>7440-05-03</cas>
  <pubchem-id>23938</pubchem-id>
  <chemical-formula>Pd</chemical-formula>
  <weight>105.903480</weight>
  <appearance>Silver-white metal.</appearance>
  <melting-point>1554.9°C</melting-point>
  <boiling-point>3167°C (5732.6°F)</boiling-point>
  <density>10.38  g·cm −3</density>
  <solubility></solubility>
  <specific-gravity nil="true"/>
  <flash-point nil="true"/>
  <vapour-pressure nil="true"/>
  <route-of-exposure>Inhalation (A21) ; oral (A21) ; dermal (A21)</route-of-exposure>
  <target nil="true"/>
  <mechanism-of-toxicity>Palladium ions are able to inhibit most major cellular fuctions. They form strong complexes with both inorganic and organic ligands, substitute essential ions, bind to amino acids and various enzymes including creatine kinase and prolyl hydroxylase, and interact with functional groups of other macromolecules such as DNA leading to strand breakage. (L798)</mechanism-of-toxicity>
  <metabolism>Palladium may be absorbed through oral, dermal, and inhalation exposure. Once in the body it distributes to the kidney, liver, spleen, lymph nodes, adrenal gland, lung and bone. Palladium and its metabolites are excreted in the urine and faeces. (A21)</metabolism>
  <toxicity nil="true"/>
  <lethaldose nil="true"/>
  <carcinogenicity>No indication of carcinogenicity to humans (not listed by IARC).</carcinogenicity>
  <use-source>Palladium is found mainly in catalytic converters and jewelry. It is also found in many electronics including computers, mobile phones, multi-layer ceramic capacitors, component plating, low voltage electrical contacts, and SED/OLED/LCD televisions. Palladium is also used in dentistry, medicine, hydrogen purification, chemical applications, and groundwater treatment. Palladium plays a key role in the technology used for fuel cells, which combines hydrogen and oxygen to produce electricity, heat and water. (L794)</use-source>
  <min-risk-level nil="true"/>
  <health-effects>Contact with palladium may cause palladium sensitivity and allergy. Animal studies have shown that palladium may damage the liver and kidney. (L798)</health-effects>
  <symptoms>Skin contact with palladium may cause contact dermatitis, erythema, and oedema. (L798)</symptoms>
  <treatment nil="true"/>
  <created-at type="dateTime">2009-03-06T18:58:14Z</created-at>
  <updated-at type="dateTime">2026-04-05T19:22:34Z</updated-at>
  <interacting-proteins>Metallothionein-2 (P02795) 
Metallothionein-1G (P13640) 
Metallothionein-1H (P80294) 
Metallothionein-3 (P25713) 
Metallothionein-1F (P04733) 
Metallothionein-1E (P04732) 
Metallothionein-1X (P80297) 
Metallothionein-1A (P04731) 
Metallothionein-1B (P07438) 
Metallothionein-1M (Q8N339) 
Metallothionein-4 (P47944) 
Metallothionein-1L (Q93083) 
(L798)</interacting-proteins>
  <wikipedia>http://en.wikipedia.org/wiki/Palladium</wikipedia>
  <uniprot-id nil="true"/>
  <kegg-compound-id></kegg-compound-id>
  <omim-id></omim-id>
  <chebi-id>33363</chebi-id>
  <biocyc-id></biocyc-id>
  <ctd-id>D010165</ctd-id>
  <stitch-id>Palladium</stitch-id>
  <drugbank-id nil="true"/>
  <pdb-id nil="true"/>
  <actor-id nil="true"/>
  <organism nil="true"/>
  <export type="boolean">true</export>
  <metabolizing-proteins nil="true"/>
  <transporting-proteins>Metallothionein-2 (P02795) 
Metallothionein-1G (P13640) 
Metallothionein-1H (P80294) 
Metallothionein-3 (P25713) 
Metallothionein-1F (P04733) 
Metallothionein-1E (P04732) 
Metallothionein-1X (P80297) 
Metallothionein-1A (P04731) 
Metallothionein-1B (P07438) 
Metallothionein-1M (Q8N339) 
Metallothionein-4 (P47944) 
Metallothionein-1L (Q93083) 
(L798)</transporting-proteins>
  <moldb-smiles>[Pd]</moldb-smiles>
  <moldb-formula>Pd</moldb-formula>
  <moldb-inchi>InChI=1S/Pd</moldb-inchi>
  <moldb-inchikey>KDLHZDBZIXYQEI-UHFFFAOYSA-N</moldb-inchikey>
  <moldb-average-mass type="decimal">106.42</moldb-average-mass>
  <moldb-mono-mass type="decimal">105.903483087</moldb-mono-mass>
  <origin>Exogenous</origin>
  <state>Solid</state>
  <logp>0</logp>
  <hmdb-id>HMDB13670</hmdb-id>
  <chembl-id nil="true"/>
  <chemspider-id>22380</chemspider-id>
  <structure-image-file-name nil="true"/>
  <structure-image-content-type nil="true"/>
  <structure-image-file-size type="integer" nil="true"/>
  <structure-image-updated-at type="dateTime" nil="true"/>
  <biodb-id nil="true"/>
  <synthesis-reference nil="true"/>
  <structure-image-caption nil="true"/>
  <chemdb-id>CHEM000163</chemdb-id>
  <dsstox-id nil="true"/>
  <toxcast-id nil="true"/>
  <stoff-ident-origin nil="true"/>
  <stoff-ident-id nil="true"/>
  <susdat-id>NS00082603</susdat-id>
  <iupac nil="true"/>
  <moldb-polar-surface-area>0.0</moldb-polar-surface-area>
  <moldb-refractivity>0.0</moldb-refractivity>
  <moldb-polarizability>1.7784</moldb-polarizability>
  <moldb-rotatable-bond-count>0</moldb-rotatable-bond-count>
  <moldb-acceptor-count>0</moldb-acceptor-count>
  <moldb-donor-count>0</moldb-donor-count>
  <moldb-pka-strongest-acidic nil="true"/>
  <moldb-pka-strongest-basic nil="true"/>
  <moldb-physiological-charge>0</moldb-physiological-charge>
  <moldb-number-of-rings>0</moldb-number-of-rings>
  <moldb-alogps-logp nil="true"/>
  <moldb-alogps-logs nil="true"/>
  <moldb-alogps-solubility nil="true"/>
</compound>
