178 2,3,4,5-Tetrachlorophenol 2,3,4,5-Tetrachlorophenol is one of several chlorophenol isomers. It is a solid with a strong medicinal taste and odor, and small amounts can be tasted in water. (L159) 25167-83-3 21013 C6H2Cl4O 229.885980 White powder. Inhalation (L159) ; oral (L159) ; dermal (L159) ; eye contact (L159) Tetrachlorophenols decrease or block ATP production without blocking the electron transport chain. Thus the poisons uncouple phosphorylation from oxidation. Free energy from the electron transport chain then converts to more body heat. As body temp rises, heat-dissipating mechanisms are overcome and metabolism is speeded. More ADP and other substrates accumulate, and these substrates stimulate the electron transport chain further. The electron transport chain responds by using up more and more available oxygen (increasing oxygen demand) in an effort to produce ATP, but much of the free energy generated is liberated as still more body heat. Oxygen demand quickly overcomes oxygen supply, and energy reserves become depleted. (A541) Tetrachlorophenols are rapidly absorbed and excreted following occupational exposure, which involves both the inhalation and dermal routes. Most of the 2,3,4,5-tetrachlorophenol is excreted unchanged in the urine; trichlorohydroquinone has been identified as one of its metabolites. (L159) LD50: >2000 mg/kg (Dermal, Rabbit) (L159) LD50: 400 mg/kg/day (Oral, Mouse) (L159) Not directly listed by IARC, but related polychlorophenols are discussed, and combined exposures to polychlorophenols or to their sodium salts are classified as possibly carcinogenic to humans (Group 2B). (L135) Exposure may result from breathing contaminated air, ingesting contaminated water or foods, and skin or eye contact, particularly while treating wood. (L159) Acute Oral: 0.01 mg/kg/day (Rat) (L159) Intermediate Oral: 0.003 mg/kg/day (Rat) (L159) Dermal exposure can cause corrosive skin damage. (L159) Dust has been found irritating to the nose and throat. Skin or eye contact can cause irritation of the exposed surface. Clinical signs preceding death for all tetrachlorophenol isomers included initial hyperactivity followed by hypoactivity, neuromuscular weakness, and convulsions. Headache can also result from exposure to 2,3,4,5-tetrachlorophenol. (L159) In case of oral exposure, dilution may enhance absorption of phenol and should be avoided, but charcoal may be administered. If methemoglobinemia occurs, administer 1 to 2 mg/kg of 1% methylene blue slowly IV in symptomatic patients. Additional doses may be required. If hypotension occurs, infuse 10 to 20 mL/kg isotonic fluid. If hypotension persists, administer dopamine or norepinephrine. Following inhalation exposure, move patient to fresh air. Monitor for respiratory distress, and if cough or difficulty breathing develops, evaluate for respiratory tract irritation, bronchitis, or pneumonitis. Administer oxygen and assist ventilation as required. Treat bronchospasm with inhaled beta2 agonist and oral or parenteral corticosteroids. Irrigate exposed eyes with copious amounts of room temperature water for at least 15 minutes following eye exposure. Following dermal exposure, remove phenol with undiluted polyethylene glycol 300 to 400 or isopropyl alcohol prior to washing, if readily available. Wash exposed areas twice or for at least 10 minutes with large quantities of soapy water. Water alone may be harmful. (T36) 2009-03-06T18:58:13Z 2026-03-31T18:15:04Z No interacting proteins found. C009408 2,3,4,5-Tetrachlorophenol true OC1=CC(Cl)=C(Cl)C(Cl)=C1Cl C6H2Cl4O InChI=1S/C6H2Cl4O/c7-2-1-3(11)5(9)6(10)4(2)8/h1,11H RULKYXXCCZZKDZ-UHFFFAOYSA-N 231.891 229.885975514 Exogenous Solid CHEMBL1528479 19766 CHEM000160 DTXSID0022220 NS00009965 20.23 47.258100000000006 18.37435061823421 0 1 1 6.331028109862445 -7.693350461142566 -1 1 4.41 -3.40 9.25e-02 g/l