113 n-Nitrosodi-n-propylamine N-Nitrosodi-n-propylamine is a chemical produced by industry in small amounts for research. Small amounts of n-nitrosodi-n-propylamine are also produced as a side reaction during some manufacturing processes, as a contaminant in some weed killers, and during the manufacture of some rubber products. It is one ingredient of cigarette. (L216) 621-64-7 12130 C6H14N2O 130.110610 Yellow liquid. 206 °C 13 mg/mL at 24 °C [MIRVISH,SS et al.(1976)] Oral (L216); inhalation (L216) ; dermal (L216). Reactive metabolites of n-nitrosodi-n-propylamine are believed to form adducts with DNA, resulting in carcinogenic effects. (L216) n-Nitrosodi-n-propylamine can be absorbed through oral, inhalation, or dermal routes. It is metabolized by cytochrome p-450 enzymes (mainly CYP 2E1) into its reactive metabolites via oxidation at the alpha, beta and gamma carbon positions. Alpha carbon oxidation is regarded as the primary pathway, resulting in formation of propionaldehyde, 1-propanol, and 2-propanol. The metabolites of n-nitrosodi-n-propylamine are excreted mainly in the urine. (L216, A152) LD50: 480 mg/kg (Oral, Rat) (T35) LD50: 487 mg/kg (Subcutaneous, Rat) (T35) 2B, possibly carcinogenic to humans. (L135) Small amounts of n-nitrosodi-n-propylamine are also produced as a side reaction during some manufacturing processes, as a contaminant in some weed killers, and during the manufacture of some rubber products. (L216) Acute Oral: 0.095 mg/kg/day (L134) High levels of n-nitrosodi-n-propylamine may damage the liver, lung, stomach, kidneys, and heart. n-Nitrosodi-n-propylamine is also a likely carcinogen. (L216) 2009-03-06T18:58:06Z 2026-03-26T18:41:19Z Cytochrome P450 2E1 (P05181) (A152) C19279 CPD-630 C013161 n-Nitrosodi-n-propylamine 1053 true Cytochrome P450 2E1 (P05181) (A152) CCCN(CCC)N=O C6H14N2O InChI=1S/C6H14N2O/c1-3-5-8(7-9)6-4-2/h3-6H2,1-2H3 YLKFDHTUAUWZPQ-UHFFFAOYSA-N 130.1882 130.11061308 Exogenous Solid CHEMBL166242 11632 CHEM000103 DTXSID6021032 NS00000640 nitrosodipropylamine