Record Information |
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Version | 1.0 |
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Creation Date | 2016-05-25 18:27:55 UTC |
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Update Date | 2016-11-09 01:17:28 UTC |
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Accession Number | CHEM022315 |
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Identification |
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Common Name | Liotrix |
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Class | Small Molecule |
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Description | Liotrix is a synthetically derived thyroid hormone replacement preparation. It consists of levothyroxine sodium (thyroxine, T4) and liothyronine sodium (triiodothyronine, T3) in a 4 to 1 ratio by weight. Liotrix was developed when it was believed that serum levels of both T4 and T3 were maintained by direct thyroidal secretion. It is now known that the thyroid gland secretes approximately ten times more T4 than T3 and that 80% of serum T3 is derived from deiodination of T4 in peripheral tissues. Administration of levothyroxine alone is sufficient for maintaining serum T4 and T3 levels in most patients and combination hormone replacement therapy generally offers no therapeutic advantage. In fact, administration of T3 may result in supratherapeutic levels of T3. |
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Contaminant Sources | - HMDB Contaminants - Urine
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Contaminant Type | Not Available |
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Chemical Structure | |
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Synonyms | Value | Source |
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Levothyroxine sodium and liothyronine sodium | Kegg | Thyrolar | Kegg | Levothyroxine sodium - liothyronine sodium mixt | KEGG | Euthyral | MeSH | Thyreotom | MeSH | Thyroxine - triiodothyronine combination | MeSH | Thyroxine - triiodothyronine combination, monosodium salt | MeSH | Thyroxine, triiodothyronine drug combination | MeSH | Triiodothyronine - thyroxine combination | MeSH | Euthroid | MeSH | Disodium (2S)-2-amino-3-[4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl]propanoate (2S)-2-amino-3-[4-(3,5-diiodo-4-oxidophenoxy)-3,5-diiodophenyl]propanoate | Generator | Disodium (2S)-2-amino-3-[4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl]propanoic acid (2S)-2-amino-3-[4-(3,5-diiodo-4-oxidophenoxy)-3,5-diiodophenyl]propanoic acid | Generator |
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Chemical Formula | C30H21I7N2Na2O8 |
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Average Molecular Mass | 1471.807 g/mol |
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Monoisotopic Mass | 1471.441 g/mol |
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CAS Registry Number | 8065-29-0 |
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IUPAC Name | disodium (2S)-2-amino-3-[4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]propanoate (2S)-2-amino-3-[4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl]propanoate |
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Traditional Name | disodium levothyroxine(1-) liothyronine(1-) |
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SMILES | [Na+].[Na+].N[C@@H](CC1=CC(I)=C(OC2=CC(I)=C(O)C=C2)C(I)=C1)C([O-])=O.N[C@@H](CC1=CC(I)=C(OC2=CC(I)=C(O)C(I)=C2)C(I)=C1)C([O-])=O |
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InChI Identifier | InChI=1S/C15H11I4NO4.C15H12I3NO4.2Na/c16-8-4-7(5-9(17)13(8)21)24-14-10(18)1-6(2-11(14)19)3-12(20)15(22)23;16-9-6-8(1-2-13(9)20)23-14-10(17)3-7(4-11(14)18)5-12(19)15(21)22;;/h1-2,4-5,12,21H,3,20H2,(H,22,23);1-4,6,12,20H,5,19H2,(H,21,22);;/q;;2*+1/p-2/t2*12-;;/m00../s1 |
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InChI Key | LKYWLLWWYBVUPP-XOCLESOZSA-L |
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Chemical Taxonomy |
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Description | belongs to the class of organic compounds known as phenylmorpholines. These are aromatic compounds containing a morpholine ring and a benzene ring linked to each other through a CC or a CN bond. |
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Kingdom | Organic compounds |
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Super Class | Organoheterocyclic compounds |
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Class | Oxazinanes |
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Sub Class | Morpholines |
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Direct Parent | Phenylmorpholines |
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Alternative Parents | |
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Substituents | - Phenylmorpholine
- Aralkylamine
- Monocyclic benzene moiety
- Benzenoid
- Tertiary amine
- Tertiary aliphatic amine
- Dialkyl ether
- Ether
- Oxacycle
- Azacycle
- Organic oxygen compound
- Organooxygen compound
- Organonitrogen compound
- Organopnictogen compound
- Hydrocarbon derivative
- Organic nitrogen compound
- Amine
- Aromatic heteromonocyclic compound
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Molecular Framework | Aromatic heteromonocyclic compounds |
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External Descriptors | |
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Biological Properties |
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Status | Detected and Not Quantified |
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Origin | Not Available |
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Cellular Locations | Not Available |
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Biofluid Locations | Not Available |
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Tissue Locations | Not Available |
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Pathways | Not Available |
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Applications | Not Available |
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Biological Roles | Not Available |
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Chemical Roles | Not Available |
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Physical Properties |
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State | Not Available |
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Appearance | Not Available |
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Experimental Properties | Property | Value |
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Melting Point | Not Available | Boiling Point | Not Available | Solubility | Not Available |
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Predicted Properties | |
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Spectra |
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Spectra | Not Available |
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Toxicity Profile |
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Route of Exposure | Not Available |
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Mechanism of Toxicity | Not Available |
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Metabolism | Not Available |
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Toxicity Values | Not Available |
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Lethal Dose | Not Available |
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Carcinogenicity (IARC Classification) | Not Available |
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Uses/Sources | Not Available |
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Minimum Risk Level | Not Available |
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Health Effects | Not Available |
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Symptoms | Not Available |
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Treatment | Not Available |
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Concentrations |
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| Not Available |
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External Links |
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DrugBank ID | DB01583 |
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HMDB ID | HMDB0015523 |
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FooDB ID | Not Available |
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Phenol Explorer ID | Not Available |
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KNApSAcK ID | Not Available |
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BiGG ID | Not Available |
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BioCyc ID | Not Available |
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METLIN ID | Not Available |
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PDB ID | Not Available |
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Wikipedia Link | Liotrix |
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Chemspider ID | Not Available |
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ChEBI ID | 6485 |
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PubChem Compound ID | 71371 |
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Kegg Compound ID | Not Available |
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YMDB ID | Not Available |
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ECMDB ID | Not Available |
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References |
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Synthesis Reference | Not Available |
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MSDS | Not Available |
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General References | Not Available |
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