Canmetcon
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Record Information
Version1.0
Creation Date2016-05-19 01:30:55 UTC
Update Date2016-11-09 01:09:15 UTC
Accession NumberCHEM003966
Identification
Common Name1,1-Dimethyl hydrazine
ClassSmall Molecule
DescriptionUnsymmetrical dimethylhydrazine is a chemical compound with the formula H2NN2. It is a colourless liquid, with a sharp, fishy, ammoniacal smell typical for organic amines. Samples turn yellowish on exposure to air and absorb oxygen and carbon dioxide. It mixes completely with water, ethanol, and kerosene. In concentration between 2.5% and 95% in air, its vapors are flammable. It is not sensitive to shock. Symmetrical dimethylhydrazine is also known but is not as useful.<ref name=Ullmann/>
Contaminant Sources
  • Clean Air Act Chemicals
  • HPV EPA Chemicals
  • IARC Carcinogens Group 2B
  • OSHA Hazardous Chemicals
  • STOFF IDENT Compounds
  • ToxCast & Tox21 Chemicals
Contaminant TypeNot Available
Chemical Structure
Thumb
Synonyms
ValueSource
1,1-DimethylhydrazinChEBI
DimazineChEBI
Gem-dimethylhydrazineChEBI
N,N-DimethylhydrazineChEBI
Unsymmetrical dimethylhydrazineChEBI
Chemical FormulaC2H8N2
Average Molecular Mass60.100 g/mol
Monoisotopic Mass60.069 g/mol
CAS Registry Number57-14-7
IUPAC Name1,1-dimethylhydrazine
Traditional Name1,1-dimethylhydrazine
SMILESCN(C)N
InChI IdentifierInChI=1S/C2H8N2/c1-4(2)3/h3H2,1-2H3
InChI KeyRHUYHJGZWVXEHW-UHFFFAOYSA-N
Chemical Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as hydrazines and derivatives. These are compounds comprising the hydrazine functional group, with the general formula R1R2NNR3R4.
KingdomOrganic compounds
Super ClassOrganonitrogen compounds
ClassHydrazines and derivatives
Sub ClassNot Available
Direct ParentHydrazines and derivatives
Alternative Parents
Substituents
  • Hydrocarbon derivative
  • Hydrazine derivative
  • Aliphatic acyclic compound
Molecular FrameworkAliphatic acyclic compounds
External Descriptors
Biological Properties
StatusDetected and Not Quantified
OriginNot Available
Cellular LocationsNot Available
Biofluid LocationsNot Available
Tissue LocationsNot Available
PathwaysNot Available
ApplicationsNot Available
Biological RolesNot Available
Chemical RolesNot Available
Physical Properties
StateNot Available
AppearanceNot Available
Experimental Properties
PropertyValue
Melting PointNot Available
Boiling PointNot Available
SolubilityNot Available
Predicted Properties
PropertyValueSource
Water Solubility976.0 mg/mLALOGPS
logP-1.1ALOGPS
logP-0.87ChemAxon
logS1.21ALOGPS
pKa (Strongest Basic)5.88ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count2ChemAxon
Hydrogen Donor Count1ChemAxon
Polar Surface Area29.26 Å2ChemAxon
Rotatable Bond Count0ChemAxon
Refractivity19.18 m3·mol-1ChemAxon
Polarizability7.05 Å3ChemAxon
Number of Rings0ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Spectra
Spectrum TypeDescriptionSplash Key
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, NegativeNot Available
Toxicity Profile
Route of ExposureNot Available
Mechanism of ToxicityNot Available
MetabolismNot Available
Toxicity ValuesNot Available
Lethal DoseNot Available
Carcinogenicity (IARC Classification)Not Available
Uses/SourcesNot Available
Minimum Risk LevelNot Available
Health EffectsNot Available
SymptomsNot Available
TreatmentNot Available
Concentrations
Not Available
DrugBank IDNot Available
HMDB IDNot Available
FooDB IDNot Available
Phenol Explorer IDNot Available
KNApSAcK IDNot Available
BiGG IDNot Available
BioCyc IDNot Available
METLIN IDNot Available
PDB IDNot Available
Wikipedia LinkUnsymmetrical dimethylhydrazine
Chemspider ID5756
ChEBI ID18853
PubChem Compound ID5976
Kegg Compound IDC19233
YMDB IDNot Available
ECMDB IDNot Available
References
Synthesis ReferenceNot Available
MSDSNot Available
General References
1. (2002) 1,1-Dimethylhydrazine. Report on carcinogens : carcinogen profiles / U.S. Dept. of Health and Human Services, Public Health Service, National Toxicology Program;Rep Carcinog;2002 ;10:107-8 (PMID: 15323050)
2. (1999) 1,1-Dimethylhydrazine. IARC monographs on the evaluation of carcinogenic risks to humans / World Health Organization, International Agency for Research on Cancer;IARC Monogr Eval Carcinog Risks Hum;1999 ;71 Pt 3:1425-36 (PMID: 10476423)
3. (2011) 1,1‑Dimethylhydrazine. Report on carcinogens : carcinogen profiles / U.S. Dept. of Health and Human Services, Public Health Service, National Toxicology Program;Rep Carcinog;2011 ;12:172-4 (PMID: 21860472)
4. (2004) 1,1-Dimethylhydrazine. Report on carcinogens : carcinogen profiles / U.S. Dept. of Health and Human Services, Public Health Service, National Toxicology Program;Rep Carcinog;2004 ;11:III107-8 (PMID: 21105246)
5. Cornish HH, Geake CL, Barth ML (1965) Biological action of 1,1-dimethylhydrazine. Biochemical pharmacology;Biochem. Pharmacol.;1965 Dec;14(12):1901-4 (PMID: 5880545)
6. Gengeliczki Z, Borkar SN, Sztáray B (2010) Dissociation of energy-selected 1,1-dimethylhydrazine ions. The journal of physical chemistry. A;J Phys Chem A;2010 May;114(20):6103-10 (PMID: 20481616)
7. CORNISH HH, BARTH ML (1964) BIOCHEMICAL RESPONSE TO 1,1-DIMETHYLHYDRAZINE (UDMH). Toxicology and applied pharmacology;Toxicol. Appl. Pharmacol.;1964 Sep;6:568-75 (PMID: 14216997)
8. Cornish HH, Hartung R (1969) The subacute toxicity of 1,1-dimethylhydrazine. Toxicology and applied pharmacology;Toxicol. Appl. Pharmacol.;1969 Jul;15:62-8 (PMID: 5798733)
9. Prager MJ (1966) Detection of 1,1-dimethylhydrazine by frustrated multiple internal reflection spectroscopy. American Industrial Hygiene Association journal;Am Ind Hyg Assoc J;1966 May-Jun;27(3):272-7 (PMID: 5961800)
10. Wong ET (1966) Renal functional response to hydrazine and 1,1-dimethylhydrazine. Toxicology and applied pharmacology;Toxicol. Appl. Pharmacol.;1966 Jan;8(1):51-6 (PMID: 5921897)