5051
T3D4992
m-Dichlorobenzene
m-Dichlorobenzene belongs to the family of Chlorobenzenes. These are compounds containing a chlorine atom attached to a benzene moiety
541-73-1
10943
C6H4Cl2
-24 C
172-173 C
Insoluble in water
Inhalation
The liver damage caused in rats by 1,3-dichlorobenzene is accompanied by induction of xenobiotic metabolizing enzymes of the phenobarbital type. In rats, a disturbance in thyroid homoeostasis can develop by hepatic enzyme induction: 1,3-dichlorobenzene induces glucuronosyl transferases. The conjugation of the thyroid hormones thyroxine (T4) and triiodothyronine (T3) is increased by the induction of glucuronosyl transferases. This leads to an increased release of T4 and T3 in the thyroid follicles.
1,3-Dichlorobenzene is readily absorbed after ingestion.
3, not classifiable as to its carcinogenicity to humans. (L135)
Acute (short-term) exposure to 1,4-dichlorobenzene, via inhalation in humans, results in irritation of the skin, throat, and eyes. Chronic (long-term) 1,4-dichlorobenzene inhalation exposure in humans results in effects on the liver, skin, and central nervous system (CNS). No information is available on the reproductive, developmental, or carcinogenic effects of 1,4-dichlorobenzene in humans. A National Toxicology Program (NTP) study reported that 1,4-dichlorobenzene caused kidney tumors in male rats and liver tumors in both sexes of mice by gavage (experimentally placing the chemical in their stomachs).
2014-10-14T21:20:40Z
2016-11-09T01:09:15Z
C19397
36693
true
ClC1=CC(Cl)=CC=C1
C6H4Cl2
InChI=1S/C6H4Cl2/c7-5-2-1-3-6(8)4-5/h1-4H
ZPQOPVIELGIULI-UHFFFAOYSA-N
147.002
145.969005542
Exogenous
Liquid
HMDB59855
13857694
CHEM003946